Coagulate - определение. Что такое Coagulate
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Что (кто) такое Coagulate - определение

PROCESS IN WHICH THE COAGULATION FACTORS OF THE BLOOD INTERACT, ULTIMATELY RESULTING A CLOT
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  • Coagulation with arrows for negative and positive feedback.
  • enzymatic activity]].
  • GPV]] allows for platelets to adhere to the site of injury. Mutations in the genes associated with the glycoprotein Ib-IX-V complex are characteristic of [[Bernard–Soulier syndrome]]
  • Modern coagulation pathway. Hand-drawn composite from similar drawings presented by Professor Dzung Le, MD, PhD, at UCSD Clinical Chemistry conferences on 14 and 21 October 2014. Original schema from Introduction to Hematology by Samuel I. Rapaport. 2nd edition;Lippencott:1987. Dr Le added the factor XI portion based on a paper from about year 2000. Dr. Le's similar drawings presented the development of this cascade over 6 frames, like a comic.
  • The interaction of vWF and GP1b alpha. The GP1b receptor on the surface of platelets allows the platelet to bind to vWF, which is exposed upon damage to vasculature. The vWF A1 domain (yellow) interacts with the extracellular domain of GP1ba (blue).

Coagulate         
·vi To undergo coagulation.
II. Coagulate ·adj Coagulated.
III. Coagulate ·vt To cause (a liquid) to change into a curdlike or semisolid state, not by evaporation but by some kind of chemical reaction; to Curdle; as, rennet coagulates milk; heat coagulates the white of an Egg.
coagulate         
[k??'agj?le?t]
¦ verb (of a fluid, especially blood) change to a solid or semi-solid state.
Derivatives
coagulable adjective
coagulation noun
coagulative adjective
coagulator noun
Origin
ME: from L. coagulat-, coagulare 'curdle'.
coagulate         
v. a., v. n.
Curdle, concrete, thicken, clot.

Википедия

Coagulation

Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The mechanism of coagulation involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of fibrin.

Coagulation begins almost instantly after an injury to the endothelium lining a blood vessel. Exposure of blood to the subendothelial space initiates two processes: changes in platelets, and the exposure of subendothelial tissue factor to plasma factor VII, which ultimately leads to cross-linked fibrin formation. Platelets immediately form a plug at the site of injury; this is called primary hemostasis. Secondary hemostasis occurs simultaneously: additional coagulation (clotting) factors beyond factor VII (listed below) respond in a cascade to form fibrin strands, which strengthen the platelet plug.

Disorders of coagulation are disease states which can result in problems with hemorrhage, bruising, or thrombosis.

Coagulation is highly conserved throughout biology. In all mammals, coagulation involves both cellular components (platelets) and proteinaceous components (here, coagulation factors). The pathway in humans has been the most extensively researched and is the best understood.

Примеры употребления для Coagulate
1. Can you grind and coagulate them for perfect conformity?
2. This is claimed to let the egg white coagulate but keep the yolk runny.
3. This lets the egg white coagulate but keep the yolk runny, regardless of egg size.
4. Committee for NATO and the nongovernmental organisation called Project on Transitional Democracies, coagulate Romania‘s strategic intentions and put content to the Romanian concerns for the Black Sea,
5. Dr Cooper told yesterday‘s hearing, at Newcastle Civic Centre, that she had been given medication to stop her blood clotting and that there was nothing to indicate that anything was wrong until she collapsed on July 2'. But in the same manner in which long–haul air passengers develop clots, her inactivity caused her blood to coagulate, which then spread through her body.